Two Genes Might Help Predict Breast Cancer Survival

Title: Two Genes Might Help Predict Breast Cancer Survival
Category: Health News
Created: 8/18/2016 12:00:00 AM
Last Editorial Review: 8/19/2016 12:00:00 AM…
To learn more visit: MedicineNet Daily News

Tamoxifen (Soltamox/Nolvadex®; AstraZeneca), an antagonist of the estrogen receptor α in ERα-positive breast cancer has been effective in most patients. The drug has been used for more than 40 years to treat breast cancers that are hormone-receptor positive. As an adjuvant therapy tamoxifen improves overall survival. Its widespread use is thought to have made a significant contribution to the reduction in breast cancer mortality seen over the last decade. [1] However, resistance to tamoxifen is a clinically significant problem.

So far, the mechanisms responsible for tamoxifen resistance remain elusive. Results from a study funded by the Dutch Cancer Society (KWF) published in Cancer Research, a journal of the American Association for Cancer Research discusses a new approach that has the potential to be used in the clinic to predict which patients with estrogen receptor-positive breast cancer will benefit from tamoxifen therapy after surgery. [2]

“We have used a very innovative approach to identify genes that help foretell whether a patient will respond to tamoxifen, and we showed that this gene signature performed well in two large patient groups,” explained René Bernards, PhD, professor and head of the Division of Molecular Carcinogenesis at the Netherlands Cancer Institute (NKI) in Amsterdam, The Netherlands.

Read the full article: Breast Cancer Treatment Response to Tamoxifen Predicted by Gene Signature. Onco’Zine – The International Oncology Network. July 17, 2014. http://adc.expert/1p10Zyu

References:
[1] Ring A, Dowsett M. Mechanisms of tamoxifen resistance. Endocr Relat Cancer. 2004 Dec;11(4):643-58.
[2]Oosterkamp HM, Hijmans EM, Brummelkamp TR, Canisius S, Wessels LF, Zwart W, Bernards R. USP9X Downregulation Renders Breast Cancer Cells Resistant to Tamoxifen. Cancer Res. 2014 Jul 15;74(14):3810-20. doi: 10.1158/0008-5472.CAN-13-1960.
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E-Cigs Have Fewer Carcinogens Than Cigarettes

But switch from tobacco didn’t reduce nicotine levels

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To learn more visit: WebMD Health

Are e-cigarettes really safe, and is the secondhand vapor bad for your health?

Read More:
Indoor exposure to vapor safer than smoke
http://www.treatobacco.net/en/page_528.php
“E-cigarette use produces a visible vapor that is usually able to be smelled, depending on the flavors and other contents of the fluid. The vapor is discharged into the air only when the user exhales (i.e. there is no sidestream vapor), in contrast to tobacco cigarettes that discharge smoke continuously while kept alight, and when the user exhales.”

Secondhand Smoke Goes Electronic With Damaging Free Radicals From E-Cig Vapor
http://www.medicaldaily.com/secondhand-smoke-goes-electronic-damaging-free-radicals-e-cig-vapor-320740
“When electronic cigarettes hit the U.S. market back in 2007, not all health care practitioners were quick to label them a safer alternative to traditional cigarettes with nicotine.”

Second-hand e-cig smoke compared to regular cigarette smoke
http://www.sciencedaily.com/releases/2014/08/140828142809.htm
“Second-hand e-cig smoke has 10 times less particulate matter than regular cigarette smoke; but higher levels of certain toxic metals, a new study finds.”
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Health official warns Zika could spread across U.S. Gulf

(Reuters) – One of the top U.S. public health officials on Sunday warned that the mosquito-borne Zika virus could extend its reach across the U.S. Gulf Coast after officials last week confirmed it as active in the popular tourist destination of Miami Beach.

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To learn more visit: Reuters: Health News

CCTV America’s Asieh Namdar spoke to Dr. Peter Hotez, the Dean of the National School of Tropical Medicine at Baylor College. Dr. Hotez also specializes in pediatrics and microbiology.
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Health official warns Zika could spread across U.S. Gulf

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A 25 year old with Epigastric Discomfort, Worse Supine, Better Sitting Up.

This is another case provided by Mustafa Alwan, an internist from Jordan, on Facebook EKG Club  
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To learn more visit: Dr. Smith’s ECG Blog

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A 25 year old with Epigastric Discomfort, Worse Supine, Better Sitting Up.

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CDC Advises Pregnant Women to Avoid Miami Beach Due to Zika

Florida Gov. Rick Scott says overall total now at 36, CDC urges pregnant women to avoid affected area

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To learn more visit: WebMD Health

Zika is top of mind for many people, especially here in South Florida. In addition to Zika, viruses around the globe such as Ebola, Chikungunya, Dengue, and West Nile are also on the rise. A new PBS documentary talks all about it, and Dr. Jonathan E Subscribe to WPBF on YouTube now for more: http://bit.ly/1qfxvbX

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Can A Nurse Practitioner Do That? (INFOGRAPHIC)

Think you need to hire a physician to fill an opening at your hospital, practice, or organization? Not necessarily: A nurse practitioner (NP) may be able to get the job done, says Tay Kopanos, DNP, NP, the Vice President of State Government Affairs for the American Association of Nurse Practitioners. As an added bonus, it typically takes less time to find a locum tenens NP to fill an open position.

<img class="alignnone size-full wp-image-112220" src="http://scrubsmag.mindovermediallc&#8230;.
To learn more visit: Scrubs – The Leading Lifestyle Nursing Magazine Featuring Inspirational and Informational Nursing Articles » Scrubs Magazine | Nurses Lifestyle

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Edwards Transcatheter Valves Now Available for A Lot More Patients

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To learn more visit: Medgadget

Oklahoma Heart Institute was the first center in the state to implant the newly FDA-approved Edwards XT valve for Transcatheter Aortic Valve Replacement (TAVR). This new valve makes this procedure available to more patients. http://oklahomaheart.com
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